Creatine really helps with depressive symptoms, especially for women.

If you want to go down the benefits of creatine supplementation on depression rabbit-hole, you can start here:

Creatine Supplementation in Depression: https://pmc.ncbi.nlm.nih.gov/articles/PMC11567172/

Creatine target engagement with brain bioenergetics: https://pmc.ncbi.nlm.nih.gov/articles/PMC4974294/

Dietary creatine intake and depression risk among U.S. adults: https://www.nature.com/articles/s41398-020-0741-x

Creatine for the Treatment of Depression: https://pmc.ncbi.nlm.nih.gov/articles/PMC6769464/

There is also a study where creatine was tested on pregnant women, and there were no side effects and helped in that study also.

What you will eventually find is that mitochondrial health, especially within brain cells can account for nearly every single mental disorder, and diseases that impact brain health (some forms of schizophrenia are virus based). This is laid out in the book Brain Energy by Chris Palmer, MD that I think should really be essential reading to anyone who endures any mental illness.

If you start to see mental disorders as more mind AND body based, it starts to make sense why exercise can have such beneficial impacts on depression and other mental disorders.

Cardio, in particular, improves mitochondrial density and health. Resistance-training helps to increase Brain-Derived Neurotropic factor (BDNF), which plays a role in growth, survival, and differentiation of nerve cells (neurons) in the brain. This is important for learning, memory, and brain plasticity. It also influences eating, drinking, and body weight regulation, along with decreasing inflammation and helping with depression.

The disorder of mitochondria can also help explain why the newest theory on serial killers are due to industrial pollution and lead toxicity, as those things can impact mitochondrial health causing other downstream issues.

So yeah, creatine, cardio and BDNF, and mitochondrial health are all related for "Brain Energy" and can help with the regulation of mental health issues.

If you have any questions or comments for me, please feel free to let me know.

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